Vitiligo and melasma are acquired pigmentary disorder of the skin and also the leading cause for dermatologist consultation in South Asian countries like Nepal. Vitiligo vulgaris and melasma are common examples for depigmentary and hyperpigmentary conditions respectively. There are multiple proven medical, surgical and combined modalities of managing them but the challenge in our part of the world with majority of Fitzpatrick skin types III-V is; it remains a psychosocial-cosmetic disease.

A 32-year-old man presented with a history of progressive, painful nodular growths with discharge consisting granules over the right thigh, inguinal area and right foot. Histopathological examination of the tissue biopsy was actinomycotic mycetoma. The patient showed improvement with trimethoprimsulfamethoxazole.The novelty of our case is to use Co-trimoxazole as a first line treatment modality for cases diagnosed or suspected as actinomycetoma.

Annular elastolylic giant cell granuloma (AEGCG) is a rare granulomatous skin disease characterized by loss of elastic fibers accompanied with elastophagocytosis by multinucleated giant cells. The clinical appearance shows annular and serpiginous plaques with hypopigmentation or skin atrophy. Ultraviolet irradiation, heat, or other unknown factors are supposed to induce pathogenic alternation [1]. The treatment for AEGCG remains unestablished and various therapeutic modalities including intralesional and systemic glucocorticoids, psoralen plus ultraviolet A irradiation, cryotherapy,retinoids, fumaric acid esters, pimecrolimus and minocycline are applied [2,3]. We report a case of AEGCG successfully treated with oral tranilast and topical glucocorticoid with sunscreens

Up to 90% of patients with psoriasis develop onychodystrophy at some point during their lives. Nail involvement precedes the skin lesions in approximately 4% of patients. We herewith report a case of a 7-year-old boy with psoriatic onychodystrophy at the age of 6 years followed by the appearance of plaque psoriasis 6 months later. The psoriatic onychodystrophy was initially misdiagnosed as onychomycosis by his family physician and was treated as such. Psoriatic onychodystrophy can clinically mimic nychomycosis and differentiation of the two conditions can be difficult. We emphasize the need for potassium hydroxide examination and culture of nail scrapings/clippings to demonstrate fungal elements, should there be doubt in the diagnosis.

Schamberg disease, also known as Schamberg purpura or progressive pigmentary purpura, is characterized by orange-brown or reddish-brown macules/patches with overlaying purpuric spots simulating cayenne pepper”. We report a 54-year-old Chinese woman with Schamberg disease presenting with purpuric macules and patches of varying sizes on the ankles, legs, and knees. The lesions were nonblanchable and nonpalpable and asymptomatic. Close inspection of the lesions revealed pinpoint petechiae resembling grains of cayenne pepper superimposed on the reddishbrown macules/patches. To our knowledge, Schamberg disease has not been reported in the scientific literature in Chinese patients.

Background: Molluscum Contagiosum is a common viral skin infection, caused by poxvirus, commonly affects young children. Although there is no specific treatment for this infection, many therapeutic modalities has been used with different success rates.